-Make a seed just for your safe house with all your crafting stations. Build some chests to hold items, or whatever you want to hold your stuff. Then make a second seed just for adventuring! When you're out mining on your second seed, instead of running back to camp you can just log out, and go back to your homestead to drop ore. And then go right back to your secondary seed to go back to collecting ore. Would not do this with wood because that stuff is everywhere, only ores really unless you're working on a masterpiece base back on your safe home!

-Make a whole bunch of fall out bases (fob) where you plan on adventuring the most, and connect them all to a hub of teleports to make getting around easier. Make some cooking stations, stations to repair your armor weapons, a bed for respawns. Make sure to keep that comfort buff up as much as you can cause it's a huge deal for regen with the new food system.

-You can put fires inside of dungeons/ruins to give you a small comfort buff. It's not much but it's a big help when dealing with powerful enemies. Often you can kill them and fall back to the fire if necessary to regen and get dry. Trust me, huge advantage. Also dont forget you can log out in dungeons too and go back to seed 1 to drop off goods!

-Food food and more food! Figure out the best combo that works for you. I mostly go balanced with my comfort buff and i do pretty alright. I try to keep balanced so i mostly do one hp, one stam, and one mixed. I leave regen to the comfort buff and me making space between the enemies and myself. Most of their most sets are easy to read so barely dodging their attacks by moving at the right time to make them leave themselves open to a counter attack is ez wins. Does not apply to skeeters, destroy them on site!!!!

-Last and not least... look up seeds that have lots of materials for things that you'd like. Like iron scraps. My first few maps i could not find a ruins in the swamps and it was driving me nuts. Now you can easily find good ones by going to some website, or just looking on steam.

Most importantly, do what makes you happy in the game! It is the best way to enjoy it in my opinion. I focus more on creation than i do progressing and i'd have to say it suits me. I love to build and create big houses or mansions. I haven't even beat the game yet and i have a blast.

Hope this helps some poor soul down the line!