After you uninstall the game, try deleting the game folder manually to remove residue files, before reinstalling. This helped many players.

If not, try lowering your Draw Distance/Level of Detail.

Also, if you used mods that added stuff that isn't in the core game, that will most likely break the game with every major patch.

Alternatively, does it still crash if you load into a different world?

No mods, crashes with dif characters, with dif worlds. The game's folder deletes itself after an un-install.