Originally posted by Olinos:

why shouldn't I though?

Steam cloud can mess up for many reasons like improper shutdown of game/computer.

Steam cloud sync seems to happen when game starts and closes. So it slows down opening games a bit but I have had no issues with corrupted saves or lost progress.

Some people have lost progress issues ... and who know what monkey wrench modding could throw in.... but if your game seems fine, like mine, I would just leave it on.

Game also has multiple saves backed up so you can go back one if it ever does mess up.
But again that is something I have not had to do.

If you play with a lot of mods and your game crashes regularly then I would avoid cloud.