I leveled my blood and elemental magic skills to around lvl 40 before trying to fight the queen solo and I guess that helped a lot. I had to spend some hours in the swamp at two draugr spawners unfortunately to get there.

In the Bossfight I didn't even bother to use my eitr to spawn skellies, just bubble yourself and spam the firestaff and try not to get hit. Also all the new potions can help a lot: Major healing, the stamina regen and the eitr potion come in really handy here.