About half my 119 hour playtime is solo, maybe more. The game can be frustrating but solo is all right.

You have to proceed into new things with more caution than in multiplayer, resource gathering for making bases and ships is more time consuming, and you can't split scouting up with other people.

On the positive, resource production is less time consuming because there's less demand, you spend less time scouting for and mining metal because you need less, and you have some hope of keeping your chests organized.