Originally posted by M'Hael:

I would suggest using bonemass and popping it as soon as you seen any 2 star coming at you in the mistlands.

This is the way. Train yourself to pop that buff anytime you see anything that looks difficult, like 2 one star's at once, or even 4 regular seekers, or really any situation that has you feeling like you might be in trouble. My other 2 tips for mistlands would be to always re-up your food as soon as possible to keep your stats up high, and always keep that rested bonus up. You can build a fireplace and sit next to it pretty much anytime to get an 8 minute rest bonus if yours ever wears off or gets low.