had no issues on my last world in plains, had a small base in the medows then went onto plains for a bigger one without walls.
made it in stone. had no issues, the lox was annoying at first before i got better weapons and armor to kill em easily.

was going to rebuild the base but i decided to just restart instead, going to do the same in this world.

For tips.. if you build near the coast, try to watch for enemy spawn points with the boat,
to see if you can find a place that does not spawn alot of enemies close to where you want to build.
and make sure that if you do build in the plains biome that you do have good armor and keep the food buffs up so the mosquitoes dont kill ya.

the stakewall can help you protect the base aswell. but i assume the mosquitoes just fly over it.

and just take it slow and dont be afraid to run away if you need to.