Originally posted by AllOutWar76:

I have this issue when I misclick while in inventory since I also run more than one monitor like you.

I do have to ask, how does it effect combat for you? You don't have a mouse pointer while using tools or weapons. My only guess is that maybe you are opening inventory during combat? If so, while we wait for an exclusive full screen a band aid fix for the time being would be to add consumables to the hot bar.

For me the mouse pointer never goes away. It is constantly on the screen and entering or exiting a menu or inventory does not get rid of it. So in order to actually aim, I have to do a lot more with my mouse, which can lead to under-turn, over-turn, or accidental turn during combat or other activities.