It is nearly impossible to die if you are an experienced gamer and actually trying, but some enemies do hit much harder than their appearance conveys even if they are not that good at landing hits in general.

Dying is so infrequent that I would rather take the skill loss than eat food for something like building, which is where most of my deaths came from; taking just a little too much fall damage at home. High or low skills don't seem to affect my chances of getting any job done, so as long as I don't lose hours of gear I'm fine with it.

I can count the rest of my deaths:
-1 death to a wolf in my first hours, before learning how stat-heavy the challenge of each biome would be.
-2 deaths to wolf packs containing a 2-star.
-1 death to a deathsquito migrating from a tiny patch of plains on an otherwise all-swamp island.
-1 death on my first encounter with a 2-star javelin fuling, bordering another swamp.
-Most recently experienced my first death to a falling tree on a fresh character. After nearly 200 hours I was surprised it finally happened.