Once the end is forgone i move on. So in Civ 5, when I know which victory is going to be mine well before the end of the game. I get OP in Skyrim and one shot just about everything. So at that point I might start a different game or if I still enjoy the one I'm on,restart with a new style or self imposed 'house rules'. I have not made it to OP in the plains here yet, but have restarted a few time now.