Yeah, I really only get nervous about naked corpse runs in the Plains, because I find it difficult to reliably evade the Deathsquito menace, and if you get two or three on you, they'll follow you to the ends of the world, and no amount of food health buffs will let you tank more than maybe two bites. Otherwise, I feel like it's best to at least try a naked run first, before risking my backup set of equipment. Even runs into the Mountains, if it's not way up a peak somewhere, can be done naked if you're careful.