Originally posted by NyuneNyuni:

getting overwhelmed by the next biome and over coming it is kinda the point, i think forest to swamp was the harder one imo

I'd agree with this, the Black Forest to Swamp transition is the biggest so far, mostly due to the biome-wide debuff of being wet, plus the big increase in threat posed by the enemies, both how hard they hit and the poison. Time will tell how the Plains to Mistlands transition stands, but I'm expecting it to be close to the Black Forest - Swamp transition.