Most recently I was doing a no-portals run, and the Bonemass swamp was quite a ways out, surrounded by plains. I didn't want to do a "beach assault" of the swamps so close to sundown, so I searched frantically for somewhere else to land and found a tiny black forest island that was attached to a tiny plains island. Neither had anything on them, so I landed, pitched my lean-to, and passed the night.

In the morning I fed myself, got in my boat and made landfall in the swamp. Just as my boat slid into land, an abomination rose up right next to the boat! I didn't want it crushing my boat that had all my worldly possessions on it, so I jumped off and tried pulling it away. I fended off a band of draugr and skeletons with some health remaining, just to be shot in the back by a draugr archer and killed!

Woke up in my undies on an empty island with leach filled water that I would drown in anyways, between me and all my stuff. Not to mention the abomination standing next to it.

I just called it permadeath and started over on a new world. :-)