So, I hate the tedium of running back and forth for resources all the time. So a lot of my mods are geared around that.

-Unrestricted Portals - Sorry, its my biggest gripe about the game. And I absolutely hate the cart.
-Plant Everything/Farm Grid - obvious reasons here. I think its silly it takes 5 real life hours for a mushroom to regrow where a tree will grow in 50 minutes. I also just like to cultivate and make an area look nice.
-Item Stacks/Skills increase weight limit - Admittedly this breaks the game flow a little more than is reasonable. But it erases the tedium for me
-Autopins - Mainly so I don't have to manually pin all the ore deposits myself

Anything with build pieces that look like they fit the overall look and feel of the game itself. I love the build pieces we have, I just want more.

I've also added Build Camera and Build in Dungeons recently just for ease of building and some fun base building in the future. At some point I'll probably add some of the other mods that add more variety to combat/gear but for now I'm content.