Most structures are static objects with few dynamic or changing values to them, and the simulation is paused for most of gameplay while no players are around.

I've been placing hundreds of 1x1 stone wall pieces inside each other around my home and never noticed any issues. More dynamic objects like fires which expend fuel might be capable of causing some losses in the long run, but if no players are around, they too are paused while players are not present AFAIK.

So are you talking about your own local world or a server?