No. I don't think you would want all the bosses. Like I said, I think the ideal might be to just have moder and yagluth for their unlocks.

I found a seed that has a perfect island, except for no meadows. I wonder how hard it would be at the start to not have leather scrap. I guess you wouldn't have honey either. You'd also be starting in black forest with nothing...

That's the challenge. You're limited to only what's available on that island. Limited iron, copper, tin, frost caves, boss items, etc. It's likely going to be mostly higher-end biomes as well if it has mistlands.