I have 1 main base that straddles meadows and plains so I can grow every type of food. Also has everything else you could possibly need.

Beyond that, I have a portal room that goes to various outposts I set up throughout the world.

This consist of a portal, chest, maybe a bed depending on where it is. All set up in ruins at strategic locations (i.e. base of a large mountain for caves. Silver, near tar pits. Etc). But almost all setup in black forests as close to these locations as possible.

Just set up a portal at your base, name it and remember the name, take a set of portal materials with you to setup the connecting portal.

If you took a ship to the location, either leave the ship there to explore further out, or break it down and take the materials through the portal and back to your main base.

First time through I made full bases everywhere. Like my new way better.