Depends what you want. Quality of life? Cheats? A harder experience?

Mods I'm currently using:

• AAACrafting: allows entering a number to craft multiple items instead of clicking a lot. Also shows how much mats you need vs have to craft that number. Also adds craftable item search, and turns the list from scrolling to pages. Most of that is configurable.
  
• Azu Skill Tweaks: allows setting modifiers for skill gain, and skill loss on death. I'm using it to reduce skill gain and increase death penalty, there was some discussion/whining about skill loss recently and I thought a low skill run could be fun.
  
• Better Pickup Notifications: changes the pickup UI, shows icons of picked up items. Might also group better but I haven't used it long enough to notice (I got sick of seeing wood & resin interleaved instead of a total for one then the other).
  
• Config Manager: provides a UI for configuring mod paramiters in game.
  
• Farming: adds a farming skill, allows plants to snap, multi plant and pickup abilities gainable and configurable skill level, time remaining at skill level, grow time.. I've nerfed it just to snapping for this run.
  
• Smooth Save: supposed to eliminate save freeze. I haven't noticed save freeze so I guess it's working.
  
• Starvation: configurable damage over time if no food eaten.
  
• Custom Raids: quite powerful, I'm only using it to increase raid likelihood (80%, up from default 20%).

There's lots more, but I'm currently in a rush for something else.