Originally posted by pipo.p:

Keep away from giant, Swiss-knife mods, and you should be fine.

Very much this. The more the mod encompasses, the likelier it is to break when something is changed in base game.

I have other reasons for not wanting to use V+, but that's neither her nor there. I'd recommend people use a mod manager (specifically I'd recommend r2modman, which is basically the same as Thunderstore Mod Manager without the overhead fluff) and just add mods as needed; makes things a ton easier for me and my servers.