No, not really. I am sure someone will come along and do it with no mods as a challenge, but I would die every few min from falling or something and boss fights would be brutal. Remember that food = healing too, so not only 25 health but you won't heal up if you take any damage at all, so eventually you die from micro falls or smoke gusts or whatnot.

what about food is a problem for you? You can get by without massive gathering sessions or gigantic farmlands. A small farm and pick up what you get 'naturally' by playing is all you need, and a few min once in a while to assemble it all.