I've noticed a tendency towards the 'conquer the current biome, kill boss, then go to next biome, rinse repeat' mindset. I do not believe that is actually the safest route.

Another path I think is safer is to get to the point you can survive without much trouble in the current biome and then after locating the boss altar and scouting it out, instead of immediately killing the boss, begin scouting the next biome. Once you've gotten a better idea what lays ahead you can make better decisions about where to place an outpost for entry point to next biome and can take the time to prepare it properly to handle the new challenges that will arise after killing the current biome's boss.

Then kill the boss.

[Edit] While scouting the next biome you may find/obtain things that will boost your progress 'prematurely' such as certain seeds and rocks. Might even farm some items from the next biome that can render the current biome boss fight trivial.

Realize that actually killing the biome boss, beyond the Forsaken Power gained, doesn't do a thing as far as making the next biome more survivable initially. More exploitable yes, survivable no.