Stay out of the water. If you cant go around, use a raft. The water has dangerous enemy, and you can run out of stamina fast.
Use poison protection potions. Most stuff will poison you there. Especially blobs.
Bring tons of arrows. And try to eliminate enemy from afar. Move slow and careful. Try not to attract mobs.
Done be afraid to retreat, and always retreat the way you came. It will be cleared of enemy.. Use the terrain and trees as cover and to slow up chasers.
And make sure you've got good food, so you can keep health and stamina up. Foods you make in a cauldron, not base foods.

edit: also make sure whatever armor/weapons you have are upgraded as much as can be. So they last longer before needing repairs.