Originally posted by Mharr:

I wouldn't build anything there for several reasons, #1 being that the shape of the terrain might change in the major update.

https://steamcommunity.com/sharedfiles/filedetails/?id=2413967409
My little home from home in the Mistlands has been safe and sound for almost a year and given the rate of roll out from Iron Gate, it may well be safe for at least another 6 months to a year LOL ;)
@OP If you need a safe place to rest up near to a swamp and this is your only option, then go for it. It may be temporary, however a simple shack with a teleport ring is a much safer and more efficient way to deal with a boss when far from home.