Originally posted by Eightball:

I ask because from reading so many recent posts it seems many players have one seed they have played for a very long time and hesitate at starting a new one.

With every character I use a new world seed to be their "home world", but I have kept certain old world files, such as the very old one my cylindrical tower is built on, and most of my characters move from world to world depending on what I feel like doing. I do, however, back up my characters and world frequently, and every time an update drops I load and resave each character and world so they don't become stale and unusable in future updates.