To be fair, I just find the nicest looking place I can (usually in the meadows) and build a base there. Then I set up a small portal hub to areas that I find that I also like and put in little bases there so I can go back and forth to my main. Yes, I do use QoL mods, most notably to move ore through portals. Most recently I've set up on an estuary that's connected to a bigger lake inland and the ocean on the other side so I can boat in and out when I please and my little port isn't affected by the big waves.