Originally posted by Faceplant8:

My last no-boss run I got all silver gear and was able to go/do whatever I wanted. Visited all the boss alters, but didn't touch. Then I decided to find my retirement location, but got bored because of no events. That was also playing no-map, no-portal, permadeath.

As for locked items, you don't need all that much iron, and now you can get iron from ML, which could be useful, although dangerous. Has anyone figured out what is locked in ML when not defeating Yag? You're going to be blind because you can't get the wisp, but I don't remember what else requires (if anything) the Torn Spirit, or wisp.

Think the 2 things not killing Yagluth would lock you out of would be the Torn Spirit to get Wisps so that you can see (optional but highly unpleasant) and getting Eggs from the Trader (highly optional). I guess you could probably look up the seed online to locate PoVs without hoping you just blunder into them. Fighting the Queen with limited vision sounds like a really bad idea.