i think the main considerations for playing solo are to just be prepared and be ready to run away if you're gonna die. the only really tedious part imo (tho others love this aspect) is building a base. if you're not gonna mod it makes sense to make your first bases near where you're gonna be extracting resources in order to gear up in a reasonable time.

also, unless you know what you're doing, it's not typically a good idea to run around at night, especially if it's raining. having no stamina is really problematic in tough fights. mostly the game is easy once you get the hang of it.