No.

Unexplored areas will spawn in any new content to that area when you first explore them. In rare cases where a world is heavily explored (not map revealed, actually explored on foot) it might be best to restart.

Though in that case, if you are up for trying one mod one time "Upgrade world" mod is one I have used to keep my original (IE started 800 hours ago) world rejuvenated with all new content to this very day