If your goal is to live there and never leave there are obviously resources you wouldn't be able to get.

I think you could obviously make it work. You would have to do without some end game food.

That's actually one thing I don't like. The mountain is such a cool biome but there is very little reason to build a base there. OTOH I'm not a big fan of the flax/barley restriction to force people to settle in the plains. Feels forced.