It also heavily depends on your mod.
It's highly unlikely the devs would change existing systems like how damage is calculated much, and stuff like UI improvements tend to be heavily advertised because that's something easy to show and amaze with.
Really I would expect something along the lines of the ice cave update, where mods will generally still work the same but won't have the new stuff included yet (which could need to new issues either way though).

The most likely thing that's gonna happen is that BepInEx is gonna give out, which in turn will shut a lot of things down, it's gonna get fixed withing a a few days and then most things will probably work again with the old stuff, with new things depending on how quickly it gets implemented by the modders.