I bought it on the first of July 2022, have been playing more or less often, one seed and one character only so far, had not a save get messed up yet. After Mistlands update the game took considerably longer to load my world the first time around, that got me worried a tiny bit, but after that it worked like always again.

Looks like a lot of people are using mods. Maybe using those increases the chance of your saves going bad. I don't use any.

But this is EA, and they might change up a lot of things, so the fear of my saves not working anymore is a latent worry I have.