Fire staff is the best weapon in the game, wearing the robes + queen buff + rested + 2 eitr foods turns you into a mass murder machine. Also, using a minor eitr potion grants essentially unlimited fire shots for about 3-5 seconds.

Also, you can use the skull to farm blood magic for the protection staff (since leveling it up with the protection staff is just agonizingly hard and slow). Once you get to 40-60 blood magic skill you can essentially replicate normal armor with the protection staff, so you can literally run any armor in the game (even being naked) and still tank hits like a champ.