Yeah. I think the heaviest hitting enemies from a biome should still be able to do meaningful damage until you have completed 2 biomes above it. So tree-wielding trolls would still be able to knock a good 50% off of you in fully upgraded wolf gear.
While minor enemies of 2 biomes above should not hit so hard that you can't survive the first hit. So if you are in basic iron gear (or fully upgraded bronze which is the same defence) you should just barely be able to survive a 0-star fuling hit.
Of course I'm simplifying. Just imagine in these examples that the vikings were eating the best but most evenly balanced diet that you would expect someone in that gear to have.

Like I literally never made healing meads because almost every time I died to an enemy, they had to make it a one-hitter.