storage space is a mess... by the current zone you have 4 pieces of armor (3+cape), weapon, shield, hoe, axe, pick, harpoon, craft hammer, bow, ammo, 3 foods, possibly a potion. If playing the new stuff weapon/shield become 3-4 weapons you swap around. You may also be hauling portal materials, and that is not to mention your other item (eg belt) or alternates (eg light hat). You can of course keep going to a base and swapping items around, eg maybe you don't carry your hoe in the plains but do in the swamp, maybe you don't carry a bow and ammo all the time but do in the ML, ... even so you are usually talking dropping off 3 or 4 items and having to make trips to get them back again as needed all the time. Could be you need a cultivator too, since you now have at least 2, if not 3 farms.

and the number of required things is slowly increasing (eg the 4 weapons or needing potions more after first few zones).
We could really use a backpack ++ storage but slow to access or some similar thing. Even pre mistlands I could not carry all the different types of loot stacks out of a mountain cave in one trip. Same now for ML area with new wood, rock, 2 wild plants, 2 bug parts per kill, soldier parts, gjall parts, soft tissue, bunny bits x 2, ... then go into a dungeon and add to all that coins, boss key collectible, jelly, 3 types of free potions, and so on... heaven help you if you get a trophy.