Originally posted by Macdallan:

Yes, absolutely fine solo, and do yourself a favour if you do play it. Don't use any mods until you give the game a fair chance without them. Mods can ruin some of the experience. Most of my 200+ hours has been solo, and every second of it has been without mods and without cheats.

I totally agree with this.
It comes down to how much time you want to put into a game.
I have 1300 hrs with 15 characters in 15 different worlds. All without mods. All but two of those worlds and characters were solo.
That said I have a lot of time to kill so i don't mind taking my time to play properly.