I agree with the "Pack for where you're going" concept. But I use portals constantly. One is my main base in Meadows. Another my Lox camp in plains that's on an island with Swamp, Black Forest, Mountains, and Plains.
A small camp in swamp that I don't use much now except for guts and bloodbags.
My exploration portal I left while exploring another big island.

I'm training 1 star wolves (trying to find 2 stars but no luck. Plenty of 1 stars tho.) in 3 different bases/camps. I had one that had all of them when I started out that got killed by stone golem (they were behing a stone wall) so now that I have a couple, I have them in my First Base in Meadows, Main Base nearby in more convenient spot, and mountain camp that's just a room for the wolves. Considering what happened to my last wolf pen, I don't want to be in a situation where I could have used a knockback weapon.
2 star wolves apparently only come out at night, so I'm spending my nights looking, then daytime going between plains portal, organizing other bases, building them up, gathering supplies in other biomes.

Since I can be a scatterbrain, it was a big bum leaving the gear I didn't need at the moment behind, going to the next portal, making a journey, only to realize I didn't bring the supplies I thought I had with me. So those filled slots are my way of saying "You're less likely to go back because you forgot something. But now you're going back since your inventory is filled up."