If you are running mods I would you recommend you disable them before the updates occur. For instance, if you are running Quick Slots remove all your stuff from the additional slots. This is one likely to break with the update (it did last time) and all your armor and whatever you have in the other extra slots will disappear forever. I imagine the same will happen if you are running a mod that allows extra big chests and larger stacking of items or additional carry weight, etc.