I see people complain about dark forest and svamp being too hard etc
mistlands isnt hard at all as long as you have the proper gear, food and skills.
it's the "end-game" biome so it should be harder and you should be strong enough.

I have end game gear and the best foods and bow skills in the 80s. Mistlands are easy as long as you don't enounter anything with too many stars or too many in a group.
but if you do end up in a situation like that, just pop bonemass and you can survive if you're good enough.
yesterday I accidently got into a fight with one soldier, 2-3 seekers and one gjall at the same time.
i just popped bonemass and tried not to panic and take them out with bow and frostner.
i survived....
sometimes you die, but that's how things should be. if you don't want to die then just enable god mode lol.

I think too many people tend to rush this game. that will only make you end up in the last biome being too weak really.
I am at day 550. I could face off the last boss but I'm in no rush really.
beating last boss doesn't serve me any purpose since there is no other boss after that one.
so I plan to max out bow skills and other things first. maybe stack up a chest of each item so I'm ready for next "expansion" then maybe I'll go for final boss.

(edit: i play solo only, no mods)