Originally posted by Gisbert:

You can level up your skill, and the stamina consumption will be reduced extremly.

This + using existing stamina food like blood pudding alongside with new stamina food and new HP food. Or just using the new health foods and face tanking seekers with root harnesk or mitigating dangers of climbing with feather fall. The game already offers you all the tools you need to overcome its challenges, even in mistlands.

Weapon durability is a bit of an issue, but you mitigate that problem by not relying solely on just one weapon type as well as increasing your skill (both weapon skill and skill at game in general).