If you don't like Yagluths location, you can find others in your world. One might suit your needs/plan.

But yeah, do some serious prep work before taking him on. Maxed armor (padded), maxed weapons (black metal and Frostner). Lots of health, stamina and fire resistance potions, Bonemass ability, set up workbenches nearby to prevent mob spawns and a portal nearby for when you die

I have a base in the Plains but not near any Yagluth alters