you need at least one base with a farm and access to several of the pulsing roots on the ground. Both can be done pretty much everywhere. I put mine with water access for the biome fish as well.

there are premade buildings larger than any you have seen before that can be repaired. I just used one of those. Everything you need for a small outpost can be portal in.

there is a flying monster that does tremendous damage to your base. I don't care to make a real base there, but you can if you want to deal with it. If you raise walls and get out of your base and engage this monster when it comes, you will be fine.