Yes. There are certain things you can construct in your build menu that actually stop spawns.
So, if you place them around in certain areas of your house/farm/base you can sort of get them to overlap each other, and eliminate spawns for good in that area.

For example, your house needs a fire & bed to sleep, so those are going to be in close proximity together, probably indoors. You will more than likley place charcoal kilns & smelters outside, so again, more spawn prevention. Same with Forge, Workbench, Stonecutter, Fermenters, etc there are more I'm forgetting, but it can be done.

So if those are all spaced out in a certain area size, you could potentially block spawns in a decent sized radius, depending how large your house or buildings/ town area is.